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BE Seminar: “Synthetic and Chemical Biology Routes to Unveiling Host-Pathogen Dialogue” (Aerin Yang, Stanford)

March 21 @ 3:30 PM - 4:30 PM

Aerin Yang

Postdoctoral Researcher, Stanford University School of Medicine

Aerin is a postdoctoral researcher at Stanford University, working with Dr. Chris Garcia. Her research centers on engineering cell surface receptors/ligands and developing protein engineering tools to study protein-protein coevolution. She earned her Ph.D. in Chemistry from KAIST, South Korea, mentored by Dr. Hee-Sung Park. Her graduate thesis focused on developing chemical biology tools for site-specific modification of proteins and investigating the fundamental mechanisms of post-translational modifications, which was recognized with multiple awards and honors, including an Agarwal Award, a Dow Chemical Award, and a Best Thesis Award from KAIST. She came to Stanford to work on engineering protein-protein interactions by interdisciplinary approaches. During her postdoctoral training, she pioneered a synthetic platform for coevolving two proteins using a “library-on-library” approach, which can be integrated with machine learning to provide unparalleled granularity in exploring protein-protein interactions. Aerin’s contributions have been published in reputable journals, and she has received recognition such as HFSP Postdoctoral Fellowships.

Research Synopsis:

Disease processes within the human body are shaped by the dynamic interplay between invading pathogens and the host’s defense mechanisms. The intricate molecular interaction involves continuous modifications of both host and pathogen proteins, driven by posttranslational modifications (PTMs) and coevolutionary mutations, to finely regulate their interactions with binding partners. In this talk, I will elucidate my research efforts aimed at unraveling these complex molecular interactions through the integration of chemical and synthetic biology approaches. Firstly, I will delve into my work about chemical biology pathways for site-specific protein modification, advancing our understanding of PTM biology. Next, I will describe the recently invented “library-on- library” approaches designed to co-evolve protein-protein interactions (PPIs). This technique addresses a pivotal challenge in understanding crucial PPIs in immunology, including those within host-pathogen interfaces.

Details

Date:
March 21
Time:
3:30 PM - 4:30 PM
Event Categories:
,

Venue

Raisler Lounge (Room 225), Towne Building

Organizer

Bioengineering
Phone
215-898-8501
Email
be@seas.upenn.edu
View Organizer Website